Reaktion #7430

Reaktionsgleichung

4-bromo-1-iodobenzene

hydrazinium hydrochloride

2,3-difluoro-4-ethoxyphenylboronic acid

sodium metaborate

→

formula 13

1-bromo-2′,3′-difluoro-4′-ethoxybiphenyl

Lösungsmittel

tetrahydrofuran

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONare then added
2. 2
   Temperaturthe mixture is refluxed for 4 hours

Vorschrift

0.450 mol of sodium metaborate are introduced into 240 ml of water. 0.012 mol of bis(triphenylphosphine)palladium(II) chloride, 0.6 mol of 4-bromo-1-iodobenzene (11) and 0.012 mol of hydrazinium hydrochloride are added, and the mixture is stirred at about 20° C. for 5 minutes. 0.6 mol of 2,3-difluoro-4-ethoxyphenylboronic acid (12) dissolved in 600 ml of tetrahydrofuran are then added, and the mixture is refluxed for 4 hours, giving the compound of the formula 13.

Quelle