Reaktion #743

ord-b3e000ca67494471adc7944fbfb45b78

Reaktionsgleichung

CC1(C)Cc2c(-c3cc(Cl)ncc3F)cnn2C1
CC1(C)Cc2c(-c3cc(Cl)
CC(C)(C)OC(=O)N[C@@H]1CCC[C@@H](C(N)=O)C1
CC(C)(C)OC(=O)N[C@@H
CC1(C)Cc2c(-c3cc(NC(=O)[C@@H]4CCC[C@@H](NC(=O)OC(C)(C)C)C4)ncc3F)cnn2C1
CC1(C)Cc2c(-c3cc(NC(
Ausbeute 84.4%

Lösungsmittel

Reaktionsbedingungen

Temperatur
100°CELSIUS

Vorschrift

Tetrakis(triphenylphosphine)palladium(0) (0.094 g, 0.08 mmol) was added to Racemic tert-butyl ((1R,3R)-3-carbamoylcyclohexyl)carbamate (0.235 g, 0.97 mmol),3-(2-chloro-5-fluoropyridin-4-yl)-5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole (0.215 g, 0.81 mmol), (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphane) (0.094 g, 0.16 mmol) and cesium carbonate (0.791 g, 2.43 mmol) in 1,4-dioxane (6 mL) and water (1.200 mL). The resulting suspension was degassed for 10 minutes under nitrogen and then stirred at 100 °C for 48 hours. LCMS is complete, it needs this long. The mixture was cooled, diluted with water (40 ml), and extracted with EtOAc (3 x 20 ml). The combined organics were evaporated to crude material. The crude product was purified by flash silica chromatography, elution gradient 0 to 60% EtOAc in heptane. Pure fractions were evaporated to dryness to afford Racemic tert-butyl ((1R,3R)-3-((4-(5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-5-fluoropyridin-2-yl)carbamoyl)cyclohexyl)carbamate (0.322 g, 84 %) as a white foam.

Quelle

750 AstraZeneca ELN dataset