Reaktion #742984

Reaktionsgleichung

nitric acid

2,6-dimethyl bromobenzene

→

yellow solid

2,6-Dimethyl-3-nitrobromo Benzene

Lösungsmittel

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled in an ice-bath (above f.p)
2. 2
   Sonstigeto come to rt
3. 3
   SonstigeReaction mixture
4. 4
   Temperaturwas cooled
5. 5
   FiltrationThe resulting yellow solid was filtered
6. 6
   Waschenwashed with ice-water
7. 7
   Sonstigedried

Vorschrift

Fuming nitric acid (83.3 mL) (>90%) was added slowly to a solution of 2,6-dimethyl bromobenzene (27.9 g, 150 mmol) in acetric acid (167 mL) and cooled in an ice-bath (above f.p). The mix was allowed to come to rt and later heated at 80° C. for 2 h. (HPLC showed no SM). Reaction mixture was cooled and poured into ice-water with stirring. The resulting yellow solid was filtered, washed with ice-water and dried to give 28.7 g of an yellow solid which was used as such in the next step.

Quelle