Reaktion #74282

Reaktionsgleichung

water

(1-benzyl-4-(4-(pyridin-4-yl)piperazin-1-yl)piperidin-4-yl)methanamine

Triethylamine

acetyl chloride

→

N-((1-Benzyl-4-(4-(pyridin-4-yl)piperazin-1-yl)piperidin-4-yl)methyl)acetamide

Ausbeute 52.0%

Lösungsmittel

dichloromethane

dichloromethane

brine

Reaktionsbedingungen

Aufarbeitung

1. 1
   TrocknenThe organic layer was dried over sodium sulfate
2. 2
   Filtrationfiltered
3. 3
   Sonstigethe solvent removed
4. 4
   SonstigeThe crude product was purified by column chromatography (silica)

Vorschrift

Triethylamine (2.5 equiv.) followed by acetyl chloride (1.2 equiv.) were added under cooled conditions to a solution of (1-benzyl-4-(4-(pyridin-4-yl)piperazin-1-yl)piperidin-4-yl)methanamine (4.67 mmol, 1 equiv.) in dichloromethane. The resulting solution was warmed to room temperature and stirred for 3 h. The mixture was diluted with dichloromethane and given water and brine washes respectively. The organic layer was dried over sodium sulfate, filtered and the solvent removed. The crude product was purified by column chromatography (silica). Yield: 52%

Quelle