Reaktion #74276

Reaktionsgleichung

tert-butyl 4-(4-cyclopropylpiperazin-1-yl)-4-(isonicotinamidomethyl)piperidine-1-carboxylate

dioxane-HCl

→

N-((4-(4-Cyclopropylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide dihydrochloride

Lösungsmittel

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was evaporated
2. 2
   Sonstigethe residue was azeotroped with dioxane (3×)

Vorschrift

To a cooled (0° C.) solution of tert-butyl 4-(4-cyclopropylpiperazin-1-yl)-4-(isonicotinamidomethyl)piperidine-1-carboxylate (0.541 mmol) in dioxane (1 ml/mmol) was added saturated dioxane-HCl solution (3.3 ml) and the reaction mixture was stirred at room temperature for 3 h. The solvent was evaporated and the residue was azeotroped with dioxane (3×). The crude product was used in the next step.

Quelle