Reaktion #74272

Reaktionsgleichung

1-benzylpiperidin-4-one

acetic acid

N-cyclopropyl piperazine

potassium cyanide

→

desired product

Ausbeute 53.0%

1-Benzyl-4-(4-cyclopropylpiperazin-1-yl)piperidine-4-carbonitrile

Ausbeute 53.0%

Lösungsmittel

methanol

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe resulting reaction mixture
2. 2
   Sonstigehad separated
3. 3
   FiltrationThe solid was collected by filtration
4. 4
   Waschenwashed with water
5. 5
   Sonstigedried

Vorschrift

To a solution of 1-benzylpiperidin-4-one (26.42 mmol, 1.0 equiv.) and acetic acid (26.42 mmol, 1.0 equiv.) in methanol (10 ml) were added water (600 ml), N-cyclopropyl piperazine (29.06 mmol, 1.1 equiv.), and potassium cyanide (26.42 mmol, 1.0 equiv.). The resulting reaction mixture was stirred at room temperature for 1 h by which time a solid had separated. The solid was collected by filtration, washed with water and dried to obtain the desired product which was used in the next step without further purification. Yield: 53%.

Quelle