Reaktion #74270

Reaktionsgleichung

(S)-indolin-2-ylmethanol

triethylamine

4-methoxy-2,6-dimethylbenzenesulfonyl chloride

→

(S)-(1-(4-Methoxy-2,6-dimethylphenylsulfonyl)indolin-2-yl)methanol

Ausbeute 72.0%

Lösungsmittel

dichloromethane

dichloromethane

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed successively with water and brine
2. 2
   Trocknendried over sodium sulfate
3. 3
   SonstigeThe solvent was evaporated under reduced pressure
4. 4
   Sonstigethe crude product was purified by silica gel column chromatography

Vorschrift

To a cold (0° C.) solution of (S)-indolin-2-ylmethanol (4.60 mmol, 1.2 equiv.) and triethylamine (2.5 equiv.) in dichloromethane (20 ml) was added dropwise 4-methoxy-2,6-dimethylbenzenesulfonyl chloride (3.83 mmol, 1.0 equiv.) in dichloromethane (5 ml) and the reaction mixture was stirred at room temperature for 2 h. The mixture was diluted with dichloromethane, washed successively with water and brine, and dried over sodium sulfate. The solvent was evaporated under reduced pressure and the crude product was purified by silica gel column chromatography. Yield: 72%.

Quelle