Reaktion #742499

Reaktionsgleichung

water

methyl 2-oxo-2,3-dihydrobenzoxazole-5-carboxylate

4-bromomethyl-1,2-dinitrobenzene

potassium carbonate

→

methyl 3-(3,4-dinitrobenzyl)-2-oxo-2,3-dihydrobenzoxazole-5-carboxylate

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with 500 ml of MTBE
2. 2
   Sonstigedried
3. 3
   Sonstigeevaporated to dryness
4. 4
   SonstigeThe residue is purified by column chromatography on silica gel

Vorschrift

2 g (10.4 mmol) of methyl 2-oxo-2,3-dihydrobenzoxazole-5-carboxylate, 2.97 g (11.4 mmol) of 4-bromomethyl-1,2-dinitrobenzene (prepared in a corresponding manner to DE 3904797) and 5.7 g (41.4 mmol) of potassium carbonate are suspended in 50 ml of acetonitrile, and the mixture is stirred at 80° C. for 1 h. The reaction mixture is poured into 50 ml of water, extracted with 500 ml of MTBE, dried and evaporated to dryness. The residue is purified by column chromatography on silica gel; product: 1.5 g;

Quelle