Reaktion #74244

Reaktionsgleichung

N-cyclohexylmethyl-benzimidazol-5-amine

4-methylthiobenzylbromide

K2CO3

→

N-(4-(Methylthio)benzyl)-N-(cyclohexylmethyl)-1H-benzo[d]imidazol-5-amine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe compound was synthesized
2. 2
   Sonstigert 18.51 min (97.8%)

Vorschrift

The compound was synthesized starting from N-cyclohexylmethyl-benzimidazol-5-amine (115 mg; 0.5 mmol; 1 eq.), 4-methylthiobenzylbromide (120 mg; 0.55 mmol; 1.1 eq.) and K2CO3 (76 mg; 0.55 mmol; 1.1 eq.) according to method 6; Yield: 0.068 g (37.3%); MS m/z: 366.4 [M+H]+; 1H-NMR (400 MHz, DMSO d6): δ 0.90-1.00 (m, 2H); 1.13-1.23 (m, 3H); 1.61-1.76 (m, 6H); 2.41 (s, 3H); 3.24 (d, 2H, 3J=6.6 Hz); 4.52 (s, 2H); 6.67-6.69 (m, 2H); 7.12-7.18 (m, 4H); 7.32-7.34 (m, 1H); 7.89 (s, 1H); 11.84 (br s, 1H); HPLC (METHOD [A]): rt 18.51 min (97.8%)

Quelle