Reaktion #74240

Reaktionsgleichung

N-(4-ethylbenzyl)benzimidazol-5-amine

(5-chlorobenzo[b]-thiophen-3-yl)methylbromide

K2CO3

→

N-(4-Ethylbenzyl)-N-((5-chlorobenzo[b]thiophen-3-yl)methyl)-1H-benzo[d]imidazol-5-amine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe compound was synthesized
2. 2
   Sonstigert 19.69 min (100%)

Vorschrift

The compound was synthesized starting from N-(4-ethylbenzyl)benzimidazol-5-amine (251 mg; 1 mmol; 1 eq.), (5-chlorobenzo[b]-thiophen-3-yl)methylbromide (288 mg; 1.1 mmol; 1.1 eq.) and K2CO3 (152 mg; 1.1 mmol; 1.1 eq.) according to method 6; Yield: 0.125 g (29.0%); MS m/z: 432.6 [M+H]+; 1H-NMR (500 MHz, DMSO d6): δ 1.14 (t, 3H, 3J=7.6 Hz); 2.55 (q, 2H, 3J=7.6 Hz); 4.64 (s, 2H); 4.85 (s, 2H); 6.79 (d, 1H, 4J=2.1 Hz); 6.84 (dd, 1H, 4J=2.1 Hz, 3J=8.9 Hz); 7.12-7.14 (m, 2H); 7.20-7.21 (m, 2H); 7.37 (d, 1H, 3J=8.9 Hz); 7.40 (dd, 1H, 4J=1.8 Hz, 3J=8.5 Hz); 7.47 (s, 1H); 7.93 (d, 1H, 4J=1.8 Hz); 7.94 (s, 1H); 8.00 (d, 1H, 3J=8.5 Hz); 12.18 (br s, 1H); HPLC (METHOD [A]): rt 19.69 min (100%)

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