Reaktion #742274

Reaktionsgleichung

cefaclor

cefaclor

ammonia

→

cefaclor monohydrate

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstige30 min
2. 2
   Sonstigeat 30° C.
3. 3
   Sonstige30 min
4. 4
   Sonstigeat 25° C.
5. 5
   Sonstige60 min
6. 6
   Sonstigeat 20° C
7. 7
   FiltrationThe suspension was filtered through a glass
8. 8
   Filtrationfilter
9. 9
   Waschenthe wet cake was washed with one volume of water and two volumes of acetone
10. 10
    SonstigeAfter drying

Vorschrift

A crystallisation reactor was filled with 34 g water and 1.0 g cefaclor as seed. The above-mentioned acidic cefaclor solution was dosed into the crystallisation reactor in 60 minutes at 35° C. The pH was kept at 5.0 with ammonia. Subsequently, the temperature was lowered in steps: 30 min at 30° C., 30 min at 25° C., and 60 min at 20° C. The suspension was filtered through a glass filter and the wet cake was washed with one volume of water and two volumes of acetone. After drying, 15.7 g cefaclor monohydrate was obtained (purity 99.4%).

Quelle