Reaktion #742251

Reaktionsgleichung

3-(2-hydroxy-phenyl)-acrylic acid ethyl ester

potassium hydroxide

→

colourless crystals

Ausbeute 51.9%

(E)-3-(2-Hydroxy-phenyl)-acrylic acid

Ausbeute 51.9%

Lösungsmittel

ethanol

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux for 28 hours
2. 2
   Einengenthe reaction mixture was concentrated
3. 3
   workup.ADDITIONThe residue was diluted with 500 ml HCl 2N
4. 4
   Extraktionextracted with ether
5. 5
   WaschenThe organic phase was washed with 2N HCl and water
6. 6
   Sonstigedried
7. 7
   Sonstigeevaporated to dryness
8. 8
   SonstigeThe resulting solid was recrystallized

Vorschrift

To a solution of 100.0 g 3-(2-hydroxy-phenyl)-acrylic acid ethyl ester in 500 ml of ethanol, a solution of 50.9 g potassium hydroxide in 500 ml of water was dropped in at room temperature. After stirring at reflux for 28 hours, the reaction mixture was concentrated. The residue was diluted with 500 ml HCl 2N and extracted with ether. The organic phase was washed with 2N HCl and water, dried and evaporated to dryness. The resulting solid was recrystallized to yield 44.3 g of colourless crystals.

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