Reaktion #74134

Reaktionsgleichung

4-[1-(4-methoxybenzyl)-3-(3-nitrophenyl)-1H-pyrazol-4-yl]-pyridine

m-chloroperbenzoic acid

→

4-[1-(4-methoxybenzyl)-3-(3-nitrophenyl)-1H-pyrazol-4-yl]pyridine 1-oxide

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONdiluted with the same solvent
2. 2
   Waschenwashed with aqueous sodium hydrogenocarbonate
3. 3
   TrocknenThe organic layer was then dried over sodium sulphate
4. 4
   Sonstigeevaporated
5. 5
   Sonstigeto afford
6. 6
   Sonstigeafter crystallization from ethylacetate, 49 mg (47%) of the title compound

Vorschrift

100 mg (0.26 mmol) of 4-[1-(4-methoxybenzyl)-3-(3-nitrophenyl)-1H-pyrazol-4-yl]-pyridine were dissolved in 3 mL of dichloromethane and 80 mg (0.52 mmol) of m-chloroperbenzoic acid were added. The mixture was stirred at room temperature for 4 hours, diluted with the same solvent and washed with aqueous sodium hydrogenocarbonate. The organic layer was then dried over sodium sulphate and evaporated to afford, after crystallization from ethylacetate, 49 mg (47%) of the title compound.

Quelle