Reaktion #74055

Reaktionsgleichung

HCl

ethyl-2-bromoisobutyrate

3-bromopyridine-2-thiol

sodium carbonate

→

ethyl 2-(3-bromopyridin-2-ylthio)-2-methylpropanoate

Ausbeute 89.1%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with ethyl acetate
2. 2
   TrocknenThe organic layer was dried over Mg2SO4
3. 3
   Einengenconcentrated
4. 4
   Sonstigepurified by chromatography

Vorschrift

A mixture of 3-bromopyridine-2-thiol (189 mg, 1 mmol), ethyl-2-bromoisobutyrate (390 mg, 2 mmol) and sodium carbonate (159 mg, 1.5 mmol) in DMF (2 mL) was heated to 70° C. for 1 hour. The reaction mixture was neutralized with HCl aq. 1M and extracted with ethyl acetate. The organic layer was dried over Mg2SO4, concentrated and purified by chromatography to yield ethyl 2-(3-bromopyridin-2-ylthio)-2-methylpropanoate (0.271 g, 89%).

Quelle