Reaktion #74047

Reaktionsgleichung

4-(3-mercaptopyridin-2-yl)benzonitrile

ethyl 2-bromo-2-methylpropanoate

K2CO3

→

ethyl 2-(2-(4-cyanophenyl)pyridin-3-ylthio)-2-methylpropanoate

Ausbeute 49.4%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenthe reaction mixture was washed with water
2. 2
   Extraktionextracted with ethyl acetate
3. 3
   TrocknenThe organic layer was dried over MgSO4
4. 4
   Einengenconcentrated
5. 5
   Sonstigepurified by chromatography

Vorschrift

A mixture of 4-(3-mercaptopyridin-2-yl)benzonitrile (0.18 g, 0.85 mmol), ethyl 2-bromo-2-methylpropanoate (0.195 g, 1 mmol), and K2CO3 (0.138 g, 1.0 mmol) in DMF (2 mL) was stirred at room temperature for 2 hours. After the reaction was completed, the reaction mixture was washed with water and extracted with ethyl acetate. The organic layer was dried over MgSO4, concentrated and purified by chromatography to yield ethyl 2-(2-(4-cyanophenyl)pyridin-3-ylthio)-2-methylpropanoate (0.137 g, 49%).

Quelle