Reaktion #73984

Reaktionsgleichung

methacryloyl chloride

trimethylsilyl propyn-1-ol

Et3N

→

2-Methyl-acrylic acid 3-trimethylsilanyl-prop-2-ynyl ester

Lösungsmittel

Et2O

Et2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAny precipitated ammonium salts can be removed by filtration, and volatile components
2. 2
   Sonstigecan be removed under reduced pressure
3. 3
   SonstigeThe crude product is then purified by flash chromatography

Vorschrift

A solution of trimethylsilyl propyn-1-ol (1 g, 7.8 mmol) and Et3N (1.4 mL, 10 mmol) in Et2O (10 mL) is cooled to −20° C. and a solution of methacryloyl chloride (0.9 mL, 9.3 mmol) in Et2O (5 mL) is added dropwise over 1 h. The mixture is stirred at this temperature for 30 min, and then allowed to warm to ambient temperature overnight. Any precipitated ammonium salts can be removed by filtration, and volatile components can be removed under reduced pressure. The crude product is then purified by flash chromatography.

Quelle