Reaktion #73919

Reaktionsgleichung

1-(bromomethyl)-4-nitrobenzene

triethyl phosphite

→

title compound

Ausbeute 89.0%

diethyl 4-nitrobenzylphosphonate

Ausbeute 89.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeInto a 250-mL round-bottom flask, was placed
2. 2
   EinengenThe resulting mixture was concentrated under vacuum

Vorschrift

Into a 250-mL round-bottom flask, was placed 1-(bromomethyl)-4-nitrobenzene (15 g, 69.77 mmol, 1.00 equiv), triethyl phosphite (70 mL). The resulting solution was stirred for 2 h at 110° C. in an oil bath. The resulting mixture was concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1:10-1:1). This resulted in 17 g (89%) of the title compound as a yellow oil.

Quelle