Reaktion #7389

Reaktionsgleichung

5-chloro-1-benzofuran-2-carboxylic acid

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title compound

5-Chloro-1-benzofuran

Lösungsmittel

1-methyl-2-pyrrolidinone

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction vessel was cooled to room temperature
2. 2
   Sonstigethe combined mixtures partitioned between water and diethyl ether
3. 3
   WaschenThe organic layer was washed with water and brine
4. 4
   Trocknendried (over magnesium sulphate)
5. 5
   Einengenconcentrated under reduced pressure

Vorschrift

To a solution of 5-chloro-1-benzofuran-2-carboxylic acid (0.2 g) in 1-methyl-2-pyrrolidinone (2 ml) was added copper granules (0.2 g). The reaction mixture was heated at 250° C. for 3.5 min in a microwave. The reaction vessel was cooled to room temperature and the mixture combined with four other similar mixtures and the combined mixtures partitioned between water and diethyl ether. The organic layer was washed with water and brine, dried (over magnesium sulphate) and concentrated under reduced pressure to give the title compound (0.65 g) as a yellow oil.

Quelle