Reaktion #738695

Reaktionsgleichung

2-Chlorobenzenesulfonic acid 3[[N-(tert-butoxycarbonyl)piperidin-4-yl]methoxy]-5-methylphenyl ester

HCl

→

title compound

Ausbeute 96.0%

2-Chlorobenzenesulfonic acid 3[(piperidin-4-yl) methoxy]-5-methylphenyl Ester

Ausbeute 96.0%

Lösungsmittel

1,4-dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was removed in vacuo
2. 2
   Sonstigethe residue was purified by flash column chromatography (10% methanol in methylene chloride saturated with. NH3)

Vorschrift

2-Chlorobenzenesulfonic acid 3[[N-(tert-butoxycarbonyl)piperidin-4-yl]methoxy]-5-methylphenyl ester (745 mg, 1.5 mmol), as prepared in the preceding step, was treated with 4 N HCl in 1,4-dioxane (20 mL) at room temperature for 2 H. The solvent was removed in vacuo and the residue was purified by flash column chromatography (10% methanol in methylene chloride saturated with. NH3) to give the title compound as a colorless syrup (570 mg 95%).

Quelle