Reaktion #73868

Reaktionsgleichung

4-bromobenzoyl chloride

THF

3-methylamino-but-2-enoic acid methyl ester

pyridine

THF

→

title compound

2-(4-Bromo-benzoyl)-3-oxo-butyric acid methyl ester

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction was warmed to room temperature over 1 hour

Vorschrift

To 3-methylamino-but-2-enoic acid methyl ester (5.0 g, 39.1 mmol) in THF (100 mL) was added pyridine (3.7 mL, 47 mmol). The mixture was cooled to 0° C., and 4-bromobenzoyl chloride (8.55 g, 39.1 mmol) in THF (30 mL) was added dropwise over 2 minutes. The reaction was warmed to room temperature over 1 hour and stirred overnight. Aqueous workup provided the title compound.

Quelle