Reaktion #738540

ord-264b37c21a2b4cc9a98721a06d1c9d94

Reaktionsgleichung

nicotine

OC[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](O)[C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@@H](O[C@H]5[C@H](O)[C@@H](O)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@@H](O[C@H]7[C@H](O)[C@@H](O)[C@@H](O[C@H]8[C@H](O)[C@@H](O)[C@@H](O[C@H]1[C@H](O)[C@H]2O)O[C@@H]8CO)O[C@@H]7CO)O[C@@H]6CO)O[C@@H]5CO)O[C@@H]4CO)O[C@@H]3CO

β-cyclodextrin

nicotine

→

CN1CCCC1c1cccnc1.OC[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](O)[C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@@H](O[C@H]5[C@H](O)[C@@H](O)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@@H](O[C@H]7[C@H](O)[C@@H](O)[C@@H](O[C@H]8[C@H](O)[C@@H](O)[C@@H](O[C@H]1[C@H](O)[C@H]2O)O[C@@H]8CO)O[C@@H]7CO)O[C@@H]6CO)O[C@@H]5CO)O[C@@H]4CO)O[C@@H]3CO

nicotine β-cyclodextrin

Edukte

Reagenzien

Keine

Lösungsmittel

H2O

water

Reaktionsbedingungen

Detaillierte Bedingungen

See reaction.notes.procedure_details.

Aufarbeitung

1
workup.ADDITIONwas added
2
workup.STIRRINGwith stirring for 10 minutes at each step
3
workup.STIRRINGwith stirring
4
workup.STIRRINGat the end of the process the granulate was stirred for 10 minutes
5
SonstigeThe obtained granulate was dried in an oven at 35° C. for 2 hours

Vorschrift

An initial quantity of 56.76 g of β-cyclodextrin was placed in a 400 mL beaker and 5.68 g of H2O (equivalent to 10% of the powder) was added with stirring. The water was added in amounts of 1.9 g at a time, with stirring for 10 minutes at each step. The powder, before addition of nicotine, was similar to a wet granulate. Next, 6.37 g of nicotine was added very slowly with stirring, and at the end of the process the granulate was stirred for 10 minutes. The obtained granulate was dried in an oven at 35° C. for 2 hours. A sample was then analyzed for nicotine content.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06280761B1uspto-grants-2001_08