Reaktion #738326

Reaktionsgleichung

(S)-2-Amino-3-(4-fluoro-phenyl)-1-(4-hydroxy-piperidin-1-yl)-propan-1-one hydrochloride

5-fluoro-1H-indole-2-carboxylic acid

→

5-Fluoro-1H-indole-2-carboxylic acid [(1S)-(4-fluoro-benzyl)-2-(4-hydroxy-piperidin-1-yl)-2-oxo-ethyl]-amide

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe crude product was triturated once with 1:1 ether-hexanes and once with hexanes
2. 2
   Filtrationthe resulting suspension filtered
3. 3
   Sonstigethe collected solid dried
4. 4
   SonstigeHPLC (60/40) 3.69 minutes (95%)

Vorschrift

(S)-2-Amino-3-(4-fluoro-phenyl)-1-(4-hydroxy-piperidin-1-yl)-propan-1-one hydrochloride (0.5 mmol) and 5-fluoro-1H-indole-2-carboxylic acid (0.5 mmol) were coupled according to Procedure A. The crude product was triturated once with 1:1 ether-hexanes and once with hexanes. The resulting solid was boiled in ethyl acetate, the resulting suspension filtered, and the collected solid dried. Yield 103 mg, 48%; HPLC (60/40) 3.69 minutes (95%); PBMS 428 (MH+, 100%);

Quelle