Reaktion #7379

Reaktionsgleichung

ammonia

tert-butyl 3-(benzoylamino)piperidine-1-carboxylate

trifluoroacetic acid

→

title compound

Ausbeute 105.6%

N-Piperidin-3-ylbenzamide

Ausbeute 105.6%

Lösungsmittel

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe mixture was concentrated under reduced pressure
2. 2
   Sonstigeto give a yellow oil which
3. 3
   Sonstigewas purified
4. 4
   WaschenSPE (silica, eluting with methanol and 5% aqueous ammonia in methanol)

Vorschrift

A solution of tert-butyl 3-(benzoylamino)piperidine-1-carboxylate (0.120 g) in DCM (5 ml) was treated with trifluoroacetic acid (5 ml) and stirred at room temperature for 6 h. The mixture was concentrated under reduced pressure to give a yellow oil which following neutralisation with aqueous ammonia solution, was purified using SPE (silica, eluting with methanol and 5% aqueous ammonia in methanol) to give the title compound (0.085 g) as an off-white solid.

Quelle