Reaktion #73777

Reaktionsgleichung

4-(4-Bromo-phenyl)-4-(4-chloro-phenyl)-piperidine

triethylamine

ethyl chloroformate

→

title compound

Ausbeute 94.0%

4-(4-Bromo-phenyl)-4-(4-chloro-phenyl)-piperidine-1-carboxylic acid ethyl ester

Ausbeute 94.0%

Lösungsmittel

dichloromethane

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with 1N HCl, saturated sodium hydrogen carbonate and brine
2. 2
   SonstigeThe organic layer was separated
3. 3
   Trocknendried (MgSO4)
4. 4
   Filtrationfiltered
5. 5
   Einengenconcentrated

Vorschrift

To a stirring suspension of 4-(4-Bromo-phenyl)-4-(4-chloro-phenyl)-piperidine* (0.28 g, 0.80 mmol) in dichloromethane (10 ml), were added triethylamine (0.45 ml, 3.2 mmol) and ethyl chloroformate (0.085 ml, 0.88 mmol). The reaction mixture was stirred for 3 hours, diluted with ethyl acetate and washed with 1N HCl, saturated sodium hydrogen carbonate and brine. The organic layer was separated, dried (MgSO4), filtered and concentrated to afford the title compound (0.29 g, 94% yield). LCMS: (PS-A2), Rt 4.02 [M+H]+ 422, 424.

Quelle