Reaktion #73770

ord-e07e8920586447e28e5753169c07dc8f

Reaktionsgleichung

CNC(=O)CC(c1ccc(Br)cc1)c1ccc(F)c(F)c1
3-(4-Bromo-phenyl)-3-(3,4-difluoro-phenyl)-N-methyl-propionamide
CC1(C)OB(c2cn[nH]c2)OC1(C)C
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
→
CNC(=O)CC(c1ccc(-c2cn[nH]c2)cc1)c1ccc(F)c(F)c1
title compound
CNC(=O)CC(c1ccc(-c2cn[nH]c2)cc1)c1ccc(F)c(F)c1
3-(3,4-Difluoro-phenyl)-N-methyl-3-[4-(1H-pyrazol-4-yl)-phenyl]-propionamide

Edukte

CNC(=O)CC(c1ccc(Br)cc1)c1ccc(F)c(F)c1
3-(4-Bromo-phenyl)-3-(3,4-difluoro-phenyl)-N-methyl-propionamide
CC1(C)OB(c2cn[nH]c2)OC1(C)C
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

3-(4-Bromo-phenyl)-3-(3,4-difluoro-phenyl)-N-methyl-propionamide was reacted with 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole following the procedure set out in Example 1 to give the title compound. LC/MS: (PS-A2) Rt 2.55 [M+H]+ 341.93.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08541461B2uspto-grants-2013_09