Reaktion #737695

Reaktionsgleichung

dihydrofolate

2,4-diamino,5-(3′,4′-dichlorophenyl),6-methylpyrimidine trimetrexate

aminopterin

pyrimethamine

trimethoprim

methotrexate

5,10-dideazatetrahydrofolate

→

pterin

Reaktionsbedingungen

Vorschrift

When in the above examples, other dihydrofolate reductase inhibitors replace methotrexate, e.g. aminopterin or 10-propargyl-5,8-dideazafolate or 2,4-diamino,5-(3′,4′-dichlorophenyl),6-methylpyrimidine trimetrexate, or pyrimethamine or trimethoprim or pyritrexim 5,10-dideazatetrahydrofolate or 10-ethyl,10-deaza-aminopterin, similar results of pterin salvage pathway blocking are obtained.

Quelle