Reaktion #73768

Reaktionsgleichung

3-(4-bromo-phenyl)-3-(4-chloro-phenyl)-N-methyl-propionamide

lithium aluminum hydride

aluminum chloride

→

desired product

Ausbeute 62.0%

[3-(4-Bromo-phenyl)-3-(4-chloro-phenyl)-propyl]-methyl-amine

Ausbeute 62.0%

Lösungsmittel

diethyl ether

diethyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturWith cooling
2. 2
   workup.ADDITIONadded
3. 3
   Sonstigequenched with addition of water
4. 4
   Extraktionextracted with ethyl acetate
5. 5
   SonstigeThe organic layer was separated
6. 6
   Trocknendried (MgSO4)
7. 7
   Filtrationfiltered
8. 8
   Einengenconcentrated
9. 9
   Sonstigethe crude product was purified over Phenomenex_Strata_SCX column chromatography
10. 10
    Wascheneluting with methanol

Vorschrift

Under a nitrogen atmosphere, the crude 3-(4-bromo-phenyl)-3-(4-chloro-phenyl)-N-methyl-propionamide was cooled to 0° C., lithium aluminum hydride (0.075 g, 1.97 mmol) and diethyl ether (3 ml) were added. With cooling, aluminum chloride (0.23 g, 1.69 mmol) was dissolved in diethyl ether (2 ml) and added. The reaction mixture was stirred for 16 hours, quenched with addition of water, basified (2N NaOH) and extracted with ethyl acetate. The organic layer was separated, dried (MgSO4), filtered and concentrated, the crude product was purified over Phenomenex_Strata_SCX column chromatography eluting with methanol followed by 2N ammonia in methanol to afford the desired product (0.254 g, 62% yield for steps 1D and 1E combined). LC/MS: (PS-B3) Rt 3.20 [M+H]+ 339.85.

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