Reaktion #73713

Reaktionsgleichung

Na2SO4

LiAlH4

35

3-[(E)-[(2,6-Diisopropylphenyl)imino](phenyl)methyl]-2′-methoxy-5-methylbiphenyl-2-ol

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title product

Ausbeute 64.2%

3-[[(2,6-Diisopropylphenyl)amino](phenyl)methyl]-2′-methoxy-5-methylbiphenyl-2-ol

Ausbeute 64.2%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added
2. 2
   SonstigeThe organic layer was separated
3. 3
   Waschenthe aqueous layer was washed by 2×50 mL of diethyl ether
4. 4
   ExtraktionThe combined organic extract
5. 5
   Sonstigewas evaporated to dryness
6. 6
   SonstigeThe product was isolated by flash-chromatography on silica gel 60 (40-63 um, eluent: from hexanes to hexanes-diethyl ether, 20:1, vol.)

Vorschrift

To a suspension of 0.34 g (8.0 mmol) of LiAlH4 in 25 mL of THF, 1.19 g (2.50 mmol) of 35 was added. The obtained mixture was stirred for 4 hr, and then a saturated aqueous solution of Na2SO4 was added. The organic layer was separated, and the aqueous layer was washed by 2×50 mL of diethyl ether. The combined organic extract was evaporated to dryness. The product was isolated by flash-chromatography on silica gel 60 (40-63 um, eluent: from hexanes to hexanes-diethyl ether, 20:1, vol.) to yield 0.77 g (64%) of the title product.

Quelle