Reaktion #736507

Reaktionsgleichung

methylamine

2-chloro-3,4-dihydro-2-(4-hydroxyphenyl)-4-methyl-3-oxo-2H-1,4-benzothiazine

ethyl acetate

water

→

titled compound

Ausbeute 89.8%

3,4-Dihydro-2-(4-hydroxyphenyl)-4-methyl-2-methylamino-3-oxo-2H-1,4-benzothiazine

Ausbeute 89.8%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe organic layer is washed with saturated aqueous sodium chloride solution
2. 2
   Trocknendried over anhydrous sodium sulfate
3. 3
   Einengenconcentrated in vacuo

Vorschrift

To a stirred suspension of 2-chloro-3,4-dihydro-2-(4-hydroxyphenyl)-4-methyl-3-oxo-2H-1,4-benzothiazine (11.5 g, compound No. 2) in tetrahydrofuran (40 ml), 40% aqueous methylamine solution (14.6 ml) is added. The mixture is stirred for 2 hours at room temperature, and poured into a mixture of ethyl acetate and water. The organic layer is washed with saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate and concentrated in vacuo to give 10.1 g (89.8%) of the titled compound.

Quelle