Reaktion #736496

Reaktionsgleichung

2-Chloro-3,4-dihydro-2-(4-hydroxyphenyl)-4-methyl-3-oxo-2H-1,4-benzothiazine

ethyl acetate

→

titled compound

3,4-Dihydro-2-hydroxy-2-(4-hydroxyphenyl)-4-methyl-3-oxo-2H-1,4-benzothiazine

Lösungsmittel

water

tetrahydrofuran

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   TrocknenThe organic layer is dried over anhydrous sodium sulfate
2. 2
   Einengenconcentrated in vacuo

Vorschrift

2-Chloro-3,4-dihydro-2-(4-hydroxyphenyl)-4-methyl-3-oxo-2H-1,4-benzothiazine (0.1 g, compound No. 2) is dissolved in a mixture of tetrahydrofuran (2 ml) and water (1 ml), and the solution is standed overnight at room temperature. The mixture is poured into a mixture of ethyl acetate and water. The organic layer is dried over anhydrous sodium sulfate, and concentrated in vacuo to give 0.1 g (quant. yield) of the titled compound as amorphous powder.

Quelle