Reaktion #736495

Reaktionsgleichung

sodium cyanide

2-chloro-3,4-dihydro-2-(4-hydroxyphenyl)-4-methyl-3-oxo-2H-1,4-benzothiazine

ethyl acetate

water

→

titled compound

Ausbeute 71.0%

2-Cyano-3,4-dihydro-2-(4-hydroxyphenyl)-4-methyl-3-oxo-2H-1,4-benzothiazine

Ausbeute 71.0%

Lösungsmittel

dimethylsulfoxide

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe organic layer is washed with water
2. 2
   Trocknendried over anhydrous sodium sulfate
3. 3
   Einengenconcentrated in vacuo

Vorschrift

To a stirred solution of 2-chloro-3,4-dihydro-2-(4-hydroxyphenyl)-4-methyl-3-oxo-2H-1,4-benzothiazine (10.0 g, compound No. 2) in dimethylsulfoxide (100 ml), sodium cyanide (8.0 g) is added. The mixture is stirred for 2 hours at room temperature, and poured into a mixture of ethyl acetate and water. The organic layer is washed with water, dried over anhydrous sodium sulfate, and concentrated in vacuo to give 6.9 g (71.0%) of the titled compound.

Quelle