Reaktion #736494

Reaktionsgleichung

thiophenol

2-chloro-3,4-dihydro-2-(4-hydroxyphenyl)-4-methyl-3-oxo-2H-1,4-benzothiazine

→

titled compound

Ausbeute 90.0%

3,4-dihydro-2-(4-hydroxyphenyl)-4-methyl-3-oxo-2-phenylthio-2H-1,4-benzothiazine

Ausbeute 90.0%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITION2) is added
2. 2
   Einengenconcentrated in vacuo
3. 3
   SonstigeThe residue is purified by silica gel column chromatography

Vorschrift

To a stirred solution of thiophenol (6.7 ml) in tetrahydrofuran (15 ml), 2-chloro-3,4-dihydro-2-(4-hydroxyphenyl)-4-methyl-3-oxo-2H-1,4-benzothiazine (4.0 g, compound No. 2) is added. The mixture is stirred for 3 hours at room temperature, and then concentrated in vacuo. The residue is purified by silica gel column chromatography to give 4.5 g (90.0%) of the titled compound.

Quelle