Reaktion #736493

Reaktionsgleichung

2-Chloro-3,4-dihydro-2-(2-hydroxy-5-methoxyphenyl)-4-methyl-3-oxo-2H-1,4-benzothiazine

methyl mercaptan

→

titled compound

Ausbeute 78.3%

3,4-Dihydro-2-(2-hydroxy-5-methoxyphenyl)-4-methyl-2-methylthio-3-oxo-2H-1,4-benzothiazine

Ausbeute 78.3%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated in vacuo
2. 2
   FiltrationThe separated crystals are collected by filtration

Vorschrift

2-Chloro-3,4-dihydro-2-(2-hydroxy-5-methoxyphenyl)-4-methyl-3-oxo-2H-1,4-benzothiazine (12.3 g, compound No. 3) is added to a mixture of 30% aqueous methyl mercaptan solution (26 ml) and tetrahydrofuran (50 ml). The mixture is stirred for 1.5 hours at room temperature and concentrated in vacuo. The separated crystals are collected by filtration to give 10.0 g (78.3%) of the titled compound.

Quelle