Reaktion #736402

Reaktionsgleichung

5-Methoxy-2-[[3-methoxy-4-(2,2,2-trifluoroethoxy)pyrid-2-yl]methylthio]benzimidazole

m-chloroperbenzoic acid

→

5-methoxy-2-[[3-methoxy-4-(2,2,2-trifluoroethoxy)pyrid-2-yl)methylsulfinyl]benzimidazole

Ausbeute 69.2%

Lösungsmittel

chloroform

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added dropwise under ice-
2. 2
   Temperaturcooling over 5 minutes
3. 3
   WaschenThe reaction mixture was washed with a saturated aqueous solution of sodium bicarbonate
4. 4
   Trocknena saturated saline, and dried with anhydrous magnesium sulfate
5. 5
   SonstigeThe solvent was evaporated
6. 6
   Sonstigethe residue was purified by column chromatography

Vorschrift

5-Methoxy-2-[[3-methoxy-4-(2,2,2-trifluoroethoxy)pyrid-2-yl]methylthio]benzimidazole (989 mg) was dissolved in chloroform (30 ml), to which a solution of m-chloroperbenzoic acid (503 mg) in chloroform (8 ml) was added dropwise under ice-cooling over 5 minutes. The reaction mixture was washed with a saturated aqueous solution of sodium bicarbonate and then a saturated saline, and dried with anhydrous magnesium sulfate. The solvent was evaporated and the residue was purified by column chromatography, to give 5-methoxy-2-[[3-methoxy-4-(2,2,2-trifluoroethoxy)pyrid-2-yl)methylsulfinyl]benzimidazole (712 mg) as a light brownish yellow powder. m.p. 36°-46° C.

Quelle