Reaktion #736399

Reaktionsgleichung

potassium

2-mercaptobenzimidazole

potassium carbonate

2-bromomethyl-4-ethoxy-3-methoxy-pyridine

→

2-[(4-ethoxy-3-methoxypyrid-2-yl)methylthio]benzimidazole

Ausbeute 68.3%

Lösungsmittel

chloroform

dimethylformamide

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added
2. 2
   Waschenwashed with water, 1N-sodium hydroxide, and water in this order
3. 3
   Sonstigedried
4. 4
   Sonstigeevaporated
5. 5
   SonstigeThe residue was purified by column chromatography on silica gel (chloroform-methanol (50:1))

Vorschrift

To a suspension of potassium salt of 2-mercaptobenzimidazole (1.3 g) and potassium carbonate (1.0 g) in dimethylformamide (15 ml) was added with stirring, a solution of 2-bromomethyl-4-ethoxy-3-methoxy-pyridine (1.6 g) in dimethylformamide (5 ml), and the mixture was stirred at room temperature for 30 minutes. The reaction mixture was diluted with chloroform (50 ml), washed with water, 1N-sodium hydroxide, and water in this order, dried, and evaporated. The residue was purified by column chromatography on silica gel (chloroform-methanol (50:1)), to give 2-[(4-ethoxy-3-methoxypyrid-2-yl)methylthio]benzimidazole (1.4 g) as a light yellow oil.

Quelle