Reaktion #736398

Reaktionsgleichung

potassium

2-mercaptobenzimidazole

2-bromomethyl-3-methoxy-4-propoxypyridine

→

2-[(3-methoxy-4-propoxypyrid-2-yl)methylthio]benzimidazole

Ausbeute 69.1%

Lösungsmittel

chloroform

dimethylformamide

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with water
2. 2
   Sonstigedried
3. 3
   Sonstigeevaporated
4. 4
   SonstigeThe residue was purified by column chromatography on silica gel (chloroform-methanol (50:1))

Vorschrift

To a solution of potassium salt of 2-mercaptobenzimidazole (0.4 g) in dimethylformamide (5 ml), was added dropwise a solution of 2-bromomethyl-3-methoxy-4-propoxypyridine (0.4 g) in dimethylformamide, and stirred at room temperature for 1 hour. The reaction mixture was diluted with chloroform (50 ml), washed with water, dried, and evaporated. The residue was purified by column chromatography on silica gel (chloroform-methanol (50:1)) to give 2-[(3-methoxy-4-propoxypyrid-2-yl)methylthio]benzimidazole (0.35 g) as a light brown oil.

Quelle