Reaktion #736396

Reaktionsgleichung

4-chloro-3-methoxy-2-methyl-pyridine

2,2,3,3,3-pentafluoropropanol

potassium tert-butoxide

→

3-methoxy-2-methyl-4-(2,2,3,3,3-pentafluoropropoxy)pyridine

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter being refluxed for 40 hours
2. 2
   workup.ADDITIONwas added
3. 3
   Filtrationthe insoluble substance was filtered off
4. 4
   EinengenThe filtrate was concentrated
5. 5
   Sonstigepurified by column chromatography

Vorschrift

To 2,2,3,3,3-pentafluoropropanol (21 ml) were added in small portions, potassium tert-butoxide (23.6 g) and then 4-chloro-3-methoxy-2-methyl-pyridine (7.5 g). After being refluxed for 40 hours, the reaction mixture was cooled, to which ethyl acetate was added and the insoluble substance was filtered off. The filtrate was concentrated and purified by column chromatography, to give 3-methoxy-2-methyl-4-(2,2,3,3,3-pentafluoropropoxy)pyridine (1.7 g) as a light yellow oil while 4.1 g of the starting material was recovered at the same time.

Quelle