Reaktion #736395

Reaktionsgleichung

4-chloro-3-methoxy-2-methylpyridine

2,2,2-trifluoroethanol

potassium t-butoxide

→

3-methoxy-2-methyl-4-(2,2,2-trifluoroethoxy)pyridine

Ausbeute 46.8%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated
2. 2
   workup.ADDITIONdiluted with water
3. 3
   Extraktionextracted twice with chloroform
4. 4
   TrocknenThe extract was dried, from which chloroform
5. 5
   Sonstigewas evaporated
6. 6
   Sonstigethe residue was purified by column chromatography on silica gel (chloroform-methanol (400:9))

Vorschrift

A mixture of 4-chloro-3-methoxy-2-methylpyridine (7.8 g), 2,2,2-trifluoroethanol (24.7 g) and potassium t-butoxide (27.76 g) was heated at 110° C. for 18 hours, then concentrated, diluted with water, and extracted twice with chloroform. The extract was dried, from which chloroform was evaporated, and the residue was purified by column chromatography on silica gel (chloroform-methanol (400:9)), to give 3-methoxy-2-methyl-4-(2,2,2-trifluoroethoxy)pyridine (5.12 g) as a white or pale yellow solid.

Quelle