Reaktion #736393

Reaktionsgleichung

4-Chloro-3-methoxy-2-methylpyridine

sodium

ethanol

→

4-ethoxy-3-methoxy-2-methyl-pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe solution was refluxed
2. 2
   Temperaturby heating for 10 hours
3. 3
   SonstigeThe solvent was evaporated
4. 4
   workup.ADDITIONthe residue was added to ice water, which
5. 5
   Extraktionwas extracted with chloroform
6. 6
   Waschenwashed with water
7. 7
   Sonstigedried
8. 8
   Sonstigeevaporated
9. 9
   SonstigeThe residue was purified by column chromatography on silica gel

Vorschrift

4-Chloro-3-methoxy-2-methylpyridine (3.14 g) was added to a solution of sodium (2.0 g) in ethanol (30 ml), and the solution was refluxed by heating for 10 hours. The solvent was evaporated and the residue was added to ice water, which was extracted with chloroform, washed with water, dried and evaporated. The residue was purified by column chromatography on silica gel, to give 4-ethoxy-3-methoxy-2-methyl-pyridine (2.6 g) as a light brown oil.

Quelle