Reaktion #736390

Reaktionsgleichung

3-Methoxy-2-methyl-4(1H)-pyridone

propyl iodide

→

3-methoxy-2-methyl-4-propoxypyridine

Lösungsmittel

chloroform

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added in small portions
2. 2
   Waschenwashed with water
3. 3
   Sonstigedried
4. 4
   Sonstigeevaporated
5. 5
   SonstigeThe residue was purified by flash chromatography (chloroform) on silica gel

Vorschrift

3-Methoxy-2-methyl-4(1H)-pyridone(1.39 g) and propyl iodide (2.0 ml) were dissolved in dimethylformamide (20 ml), to which silver oxide (2.31 g) was added in small portions and stirred vigorously at room temperature for 5 hours. The reaction mixture was diluted with chloroform (100 ml), washed with water, dried and evaporated. The residue was purified by flash chromatography (chloroform) on silica gel, to give 3-methoxy-2-methyl-4-propoxypyridine (1.7 g) as a light brown oil.

Quelle