Reaktion #73620

Reaktionsgleichung

4-trifluoromethylbenzoyl chloride

2-amino-4-methylthiazole-5-carboxylic acid benzylamide

→

title compound

Ausbeute 45.0%

4-Methyl-2-(4-trifluoromethylbenzoylamino)thiazole-5-carboxylic Acid Benzylamide

Ausbeute 45.0%

Reaktionsbedingungen

Vorschrift

Following the procedure as described in Example 2, making variations only as required to use 4-trifluoromethylbenzoyl chloride in place of benzoyl chloride to react with 2-amino-4-methylthiazole-5-carboxylic acid benzylamide, the title compound was obtained as a white solid in 45% yield; 1H NMR (CDCl3, 300 MHz) δ 8.05 (d, J=8.2 Hz, 2H), 7.77 (d, J=8.2 Hz, 2H), 7.36-7.29 (m, 5H), 5.97 (s, 1H), 4.60 (d, J=5.6 Hz, 2H), 2.57 (s, 3H); MS (ES+) m/z 420.1 (M+1).

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