Reaktion #736191

Reaktionsgleichung

7-methylbenzo[b]thiophene

water

n-butyllithium

→

title compound

2-Fluoro-7-methylbenzo[b]thiophene

Lösungsmittel

hexane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONtetryhydrofuran are added dropwise at -78°
2. 2
   Temperaturis maintained below -60°
3. 3
   TemperaturAfter 30 minutes at -78° the temperature is slowly raised to 0°
4. 4
   Sonstigethe organic phase separated
5. 5
   Waschenwashed
6. 6
   Sonstigedried
7. 7
   Einengenconcentrated under vacuum
8. 8
   SonstigeThe residue is chromatographed (eluant: n-hexane)

Vorschrift

To a solution of 7 g of 7-methylbenzo[b]thiophene in abs. tetryhydrofuran are added dropwise at -78°, 30 ml of a 1.6M solution of n-butyllithium in hexane. After 20 minutes 5.5 g of perchloryl fluoride are introduced whereby the reaction temperature is maintained below -60°. After 30 minutes at -78° the temperature is slowly raised to 0°. The mixture is then mixed with water and the organic phase separated, washed, dried and concentrated under vacuum. The residue is chromatographed (eluant: n-hexane) to obtain the title compound as an oil.

Quelle