Reaktion #73584

ord-bb7f28c0f0144c43ad84ff9519be4688

Reaktionsgleichung

CN(C)C(=N)NC(=N)N
metformin
Cl
hydrochloric acid
→
CN(C)C(=N)N=C(N)N.Cl
metformin hydrochloride
Ausbeute 76.4%

Edukte

CN(C)C(=N)NC(=N)N
metformin
Cl
hydrochloric acid

Reagenzien

Keine

Lösungsmittel

CC(C)=O
acetone

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    FiltrationThe resulting crystal was filtered
  2. 2
    Waschenwashed with acetone
  3. 3
    Sonstigedried
  4. 4
    Temperaturwith heated air at 70° C.

Vorschrift

500 mg of metformin free base was dissolved in 30 Ml of acetone, and then 280 Ml of concentrated hydrochloric acid was added, and stirred for 2 hours at room temperature. The resulting crystal was filtered and washed with acetone, and then dried with heated air at 70° C. to obtain 490 mg of metformin hydrochloride (yield: 76.4%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08541474B2uspto-grants-2013_09