Reaktion #735752

Reaktionsgleichung

2-amino-4-methyl-5-acetylthiazole

pyridinium hydrobromide

→

2-amino-4-methyl-5-(2-bromoacetyl)thiazole hydrobromide

Lösungsmittel

hydrogen bromide

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe precipitate was collected by filtration
2. 2
   Waschenwashed with diisopropyl ether
3. 3
   Trocknendried over calcium chloride

Vorschrift

To a suspension of 2-amino-4-methyl-5-acetylthiazole (15.6 g) in 30% of hydrogen bromide in acetic acid (120 ml) was added pyridinium hydrobromide perbromide (36 g) at ambient temperature and the mixture was stirred at the same temperature for 5 hours. The precipitate was collected by filtration, washed with diisopropyl ether, and dried over calcium chloride to give 2-amino-4-methyl-5-(2-bromoacetyl)thiazole hydrobromide (26.8 g).

Quelle