Reaktion #73514

ord-d1346910ee874305bbc5ae3d9da8c090

Reaktionsgleichung

CCOC(=O)CC(=O)C(Cc1ccccc1)C(=O)OCC
diethyl 2-benzyl-3-oxopentanedioate
CCN(c1ccccc1)S(=O)(=O)c1ccc(NN)nc1
N-ethyl-6-hydrazino-N-phenylpyridine-3-sulfonamide
CC(=O)[O-]
acetate
→
CCOC(=O)Cc1[nH]n(-c2ccc(S(=O)(=O)N(CC)c3ccccc3)cn2)c(=O)c1Cc1ccccc1
ethyl (4-benzyl-1-{5-[ethyl(phenyl)sulfamoyl]pyridin-2-yl}-5-oxo-2,5-dihydro-1H-pyrazol-3-yl)acetate

Edukte

CCOC(=O)CC(=O)C(Cc1ccccc1)C(=O)OCC
diethyl 2-benzyl-3-oxopentanedioate
CCN(c1ccccc1)S(=O)(=O)c1ccc(NN)nc1
N-ethyl-6-hydrazino-N-phenylpyridine-3-sulfonamide
CC(=O)[O-]
acetate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigeare obtained in the form of a white powder

Vorschrift

According to the process described in Example 1.3, starting with 5 g (17.1 mmol) of diethyl 2-benzyl-3-oxopentanedioate and 5 g (17.1 mmol) of N-ethyl-6-hydrazino-N-phenylpyridine-3-sulfonamide, 3 g of ethyl 4-benzyl-1-{5-[ethyl(phenyl)sulfamoyl]pyridin-2-yl}-5-oxo-2,5-dihydro-1H-pyrazol-3-yl)acetate are obtained in the form of a white powder.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08541455B2uspto-grants-2013_09