Reaktion #7348
ord-2462d807654541a2a1bf0f369b69e9aa
Reaktionsgleichung
6b
4-Bromo-2-(3-fluoro-4-hydroxyphenyl)quinolin-6-ol
4-pyridinylboronic acid
→
2-(3-Fluoro-4-hydroxyphenyl)-4-(4-pyridinyl)quinolin-6-ol
Ausbeute 20.0%
Reagenzien
Keine
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Vorschrift
This compound was prepared from 6b using 4-pyridinylboronic acid according to method P. Yellow powder; Yield: 20%; mp>350° C. (dec.); 1H-NMR (400 MHz, DMSO-d6) δ 7.02 (d, J=2.6 Hz, 1H), 7.07 (t, J=8.8 Hz, 1H), 7.34 (dd, J=9.0, 2.6 Hz, 1H), 7.64 (d, J=5.9 Hz, 2H), 7.93 (s, 1H), 7.95–8.00 (m, 2H), 8.08 (dd, J=13.0, 2.1 Hz, 1H), 8.79 (d, J=3.9, 2H), 10.02 (s, 1H), 10.22 (s, 1H); MS (ESI) m/z 331 ([M−H]−), 333 ([M+H]+); Anal. Calcd for C20H13FN2O2: C: 72.28, H: 3.94, N: 8.43. Found: C: 70.79, H: 4.08, N: 7.87.