Reaktion #734681

Reaktionsgleichung

methyl-p-(bromomethyl)toluate

4-mercaptopyridine

triethylamine

→

methyl 4-((4-pyridinylthio)methyl)benzoate

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed for 16 hours
2. 2
   WaschenThe reaction mixture was washed twice with 300 ml of water
3. 3
   TrocknenThe toluene layer was dried over anhydrous sodium sulfate
4. 4
   Einengenconcentrated
5. 5
   Sonstigeto give a dark red oil which
6. 6
   Temperaturupon cooling

Vorschrift

A mixture containing 11.0 grams of methyl-p-(bromomethyl)toluate (0.048 mole), 5.3 grams of 4-mercaptopyridine (0.048 mole), 25 ml of triethylamine and 200 ml of toluene was refluxed for 16 hours and then cooled to room temperature. The reaction mixture was washed twice with 300 ml of water. The toluene layer was dried over anhydrous sodium sulfate and then concentrated to give a dark red oil which solidified upon cooling.

Quelle