Reaktion #7345
ord-abdf39d15bf8495fba05b5d7db69b61a
Reaktionsgleichung
6b
4-Bromo-2-(3-fluoro-4-hydroxyphenyl)quinolin-6-ol
4-cyanophenylboronic acid
→
4-(4-Cyanophenyl)-2-(3-fluoro-4-hydroxyphenyl)quinolin-6-ol
Ausbeute 52.0%
Reagenzien
Keine
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Vorschrift
This compound was prepared from 6b using 4-cyanophenylboronic acid according to method P. Yellow powder; Yield: 52%; mp 266–267° C.; 1H-NMR (400 MHz, DMSO-d6) δ 6.97 (d, J=2.7 Hz, 1H), 7.07 (t, J=8.8 Hz, 1H), 7.34 (dd, J=9.0, 2.6 Hz, 1H), 7.82 (d, J=8.5 Hz, 2H), 7.92 (s, 1H), 7.95–8.00 (m, 2H), 8.07–8.10 (m, 3H), 10.00 (s, 1H), 10.21 (s, 1H); MS (ESI) m/z 355 ([M−H]−), 357 ([M+H]+); Anal. Calcd for C22H13FN2O2: C: 74.15, H: 3.68, N: 7.86. Found: C: 73.69, H: 3.53, N: 7.86.