Reaktion #73435

Reaktionsgleichung

(5-Cyclopropyl-isoxazol-3-yl)-carbamic acid phenyl ester

NCS

→

title compound

(4-Chloro-5-cyclopropyl-isoxazol-3-yl)-carbamic acid phenyl ester

Lösungsmittel

AcOH

water

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction is cooled to room temperature
2. 2
   WaschenThe organic layer is washed with 500 mL of water
3. 3
   Sonstigeto remove the acid
4. 4
   TrocknenThe organic layer is dried (sodium sulfate)
5. 5
   Einengenconcentrated to an oil (352 mg)

Vorschrift

(5-Cyclopropyl-isoxazol-3-yl)-carbamic acid phenyl ester (0.25 g, 1.024 mmol) is dissolved in AcOH (7.31 mL) and NCS (0.205 g, 1.53 mmol) is added and the reaction is heated to 79° C. for 2 hours. The reaction is cooled to room temperature and diluted with water and ethyl acetate. The organic layer is washed with 500 mL of water to remove the acid. The organic layer is dried (sodium sulfate) and concentrated to an oil (352 mg) to obtain the title compound that is used without further purification. MS (ESI) m/z 279.00 (M+1).

Quelle