Reaktion #734148

Reaktionsgleichung

3-methyl-4-[3-(4-methyl-piperazin-1-yl)-propoxy]-benzaldehyde

4-tert-butyl-benzene-1,2-diamine

→

title compound

Ausbeute 81.0%

5-tert-Butyl-2-{3-methyl-4-[3-(4-methyl-piperazin-1-yl)-propoxy]-phenyl}-1H-benzoimidazole

Ausbeute 81.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThis compound was prepared by the method
2. 2
   SonstigePurification by Method 2

Vorschrift

This compound was prepared by the method described in Example 1, using 3-methyl-4-[3-(4-methyl-piperazin-1-yl)-propoxy]-benzaldehyde (516 mg, 1.87 mmol, 1.0 equiv), 4-tert-butyl-benzene-1,2-diamine (307 mg, 1.87 mmol, 1.0 equiv), and Na2S2O5 (461 mg, 2.43 mmol, 1.3 equiv) in General Procedure 3. Purification by Method 2 afforded 633 mg (81%) of the title compound. MS (electrospray): mass calculated for C26H36N4O, 420.29. m/z found, 421.5 [M+H]+. 1H NMR (400 MHz, CD3OD): 7.90-7.85 (m, 2H), 7.65-7.40 (m, 2H), 7.33 (d, J=8.5 Hz, 1H), 7.04 (d, J=8.1 Hz, 1H), 4.14-4.11 (m, 2H), 2.90-2.28 (m, 16H), 2.06-2.03 (m, 2H), 1.39 (s, 9H).

Quelle